The anti-aging supplement Nicotinamide riboside chloride: Is it a safe and effective?

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As we all know, the strength of mitochondrial function determines an important factor in the human body state. Mitochondria are the reason why we exist today as complex animals rather than bacteria. Almost every cell contains these tiny strange-shaped organelles, called mitochondria, also known as "the powerful cells of the cell." These tiny organs are responsible for generating 90% of the energy required by the human body. The more powerful the mitochondria, the younger our body, and vice versa.

NAD+ factor is a key method to maintain the health of mitochondria. Our cells naturally produce this molecule and use it to maintain the normal operation of various organs in the body. But we also know that the NAD + supply in the human body will decrease with age and metabolic stress factors (such as drinking, overeating, excessive sun exposure and sleep disturbance). When this factor is lacking, our body starts There are aging phenomena and various diseases. Therefore, maintaining the level of NAD + may be the key to maintaining cell health. Finding a natural and healthy way to increase the body's NAD+ has become a problem that researchers have been exploring.

The discovery of NR undoubtedly gave researchers hope. NR is a natural product and a vitamin that has been hidden in milk. This relatively unknown form of vitamin B3 can significantly increase his NAD + level safely, quickly and without any adverse side effects. It was first discovered by scientists in yeast in the 1940s, but it was not until the early 2000s that scientists discovered that this third form of vitamin B3 not only increases NAD +, but also improves human health.

Nicotinamide ribose NR once again entered people’s field of vision in the study of nutrition and metabolism at the beginning of the 21st century. In addition to previous studies found that it has a certain inhibitory effect on obesity, researchers also found that it can effectively inhibit the senescence of stem cells in elderly mice Extend the life span of mice.

 

What is Nicotinamide riboside chloride(NRC)?

Nicotinamide riboside chloride(also known as NRC), it is the chlorinated form of nicotinamide riboside. NRC also is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

Nicotinamide riboside chloride has positive effects on preventting muscle, neural and melanocyte stem cell senescence. Studies have also found that it may improve the regeneration of organs such as the liver, kidneys and heart. While reducing blood sugar and fatty liver in pre-diabetes and type 2 diabetes models, it can also prevent the development of diabetic peripheral neuropathy.

 

Does Nicotinamide riboside chloride reverse aging?

NAD+ is a vital substance for human life activities. Without it, your body will have various disease problems. Nicotinamide riboside is the precursor of NAD+, which is changed in the body to a chemical called NAD+. When NAD+ is lacking in the body, it produces NAD+ that makes the body return to normal work.

The weakening of mitochondrial function is an important factor leading to human aging. Boosting NAD+ can promote healthy mitochondrial function, so as to achieve the effect of regulating life span and delaying or even reversing aging.

Taking nicotinamide riboside can help raise these low NAD+ levels, so as to maintain the normal operation of all parts of the body, to keep people young.

 

Is Nicotinamide riboside chloride safe for anti-aging?

NR is a natural product and a vitamin that has been hidden in milk. It is very safe for the human body and has almost no side effects. Clinical trials have found that NRC and other supplements can be taken safely and do not negatively affect drugs. However, niacin is generally not suitable for NAD+ enhancement because it has uncomfortable skin flushing side effects.

In 2016, the FDA approved nicotinamide ribose as a generally recognized safe food ingredient, including energy water (a beverage that adds some additional ingredients to drinking water), protein shakes, nutrition bars, etc. The no-observed-adverse-effect level (NOAEL) NOAEL and the lowest observed adverse effect level (LOAEL) of rodents are 300 and 1000 mg/kg/day, respectively.

 

How do you increase Nicotinamide riboside chloride naturally?

The NAD+ factor in the human body will gradually decrease with age, and aging and illness will also follow. In order to prevent diseases and delay aging, we can increase the level of life factors in the body by supplementing some vegetables, fruits and nutritional health products that are rich in NAD+ or NR.

In foods, milk is the most common source of NR factors. NR is a natural product and a vitamin that has been hidden in milk. In addition, the fish and mushrooms that we often eat are also rich in NR factors.

In addition, many nutritional supplements on the market also contain NRC ingredients, which may appear in different forms, which can be powders, capsules, tablets or preparations.

No matter which way to supplement NRC, just choose the one that suits you best is the best.

 

Where can we get the best Nicotinamide riboside chloride?

There are many types of NRCs sold on the market in various forms. You can buy nicotinamide ribose chloride at your local health food store, pharmacy or online store. Whether you want bulk pharmaceutical-grade powders or certain food-grade supplements, make sure to look for a real supplier. The benefit of virtual shopping is that you can compare prices and view real-time customer feedback. However, you are also likely to fall for the counterfeit.

Phcoker is a trusted brand, and all our products follow quality control measures. We deal with different chemicals and dietary supplements. Please contact us for your order and friendly quotation.

 

Reference:

[1]Bieganowki, P. & Brenner, C. (2004). "Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans". Cell. 117: 495–502. doi:10.1016/s0092-8674(04)00416-7. PMID 15137942

[2]Bogan, K.L. & Brenner, C. (2008). Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ precursor Vitamins in Human Nutrition. Annual Review of Nutrition.

[3]Dominique Turck, Jacqueline Castenmiller etc. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J, 2019 Aug 7;17(8):e05775. doi: 10.2903/j.efsa.2019.5775. eCollection 2019 Aug. PMID: 32626405.